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To date there are several credible patient studies and two double blind, placebo-controlled studies completed. These are summarized below.

The first patient study was conducted by Dr Len Sands of the San Diego Clinic.  He  completed a human study on the effectiveness on Cetyl Myristoleate in 1995. There were 48 arthritis patients in this study. All but two showed significant improvement in articular mobility (80% or better) and reduction of pain (70% or better). This study had serious flaws, but was nevertheless useful as it suggested to many that maybe there was some hope here and that more scientific studies should follow. 

The first double blind study followed two years later. Dr. H. Siemandi conducted a double blind study under the auspices of the Joint European Hospital Studies Program. There were 431 patients in the study, 106 who received cetyl myristoleate, 99 who received cetyl myristoleate and glucosamine, sea cucumber, and hydrolyzed cartilage; and 226 who received a placebo. Clinical assessment included radiological test and other studies. Results were 63% improvement for the cetyl myristoleate group, 87% for the cetyl myristoleate plus glucosamine group and 15% for the placebo group.

In August of 2002, a double blind study was published in the Journal or Rheumatology. The study included sixty-four patients with chronic knee OA. Half of the patients received a cetyl myristoleate complex and half a placebo. Evaluations included physician assessment, knee range of motion with goniometry, and the Lequesne Algofunctional Index (LAI). The conclusion was that the CM group saw significant improvement while the placebo group saw little to none. In fact in their conclusion they state that CM "may be an alternative to the use of nonsteroidal anti-inflammatory drugs for the treatment of OA".

Advanced Medical Systems & Design, Ltd completed a study in Oct 2001. It was not a double blind study but the study included 1814 arthritis patients. The results showed that over 87% of the subjects had greater than 50% recovery and over 65% of those showed from 75% - 100% recovery following a sixteen day regimen. This is not a scientific study but a study with this may patients does suggest that there could be a positive benefit to the use of CM in the treatment of arthritis.